منابع مشابه
Beneficial effect of albumin therapy attributable to alpha1-acid glycoprotein?
Attributable to a1-Acid Glycoprotein? To the Editor: Belayev et al1 report that albumin therapy has the beneficial effect of reversing stagnation, thrombosis, and corpuscular adherence in the cortical venules of a rat model of middle cerebral artery occlusion. They cite further studies in which human serum albumin treatment conferred neurological and histological protection in rat stroke models...
متن کاملLeukocyte surface origin of human alpha1-acid glycoprotein (orosomucoid)
Specific antibodies against human alpha1-acid glycoprotein reacted with human lymphocytes, granulocytes, and monocytes. The antigen on the leukocytes is an externally located integral membrane glycoprotein which is made by the cells and has an apparent mol wt of 52,000. It is released from cells in vitro to the culture medium. The mol wt of the soluble fragment is 41,000, which corresponds to t...
متن کاملEffects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine.
OBJECTIVE UCN-01 (7-hydroxystaurosporine) is a small molecule cyclin-dependent kinase modulator currently under clinical development as an anticancer agent. In vitro studies have demonstrated that UCN-01 is strongly bound to the acute-phase reactant alpha (1)-acid glycoprotein (AAG). Here, we examined the role of protein binding as a determinant of the pharmacokinetic behavior of UCN-01 in pati...
متن کاملDifferential effects of alpha1-acid glycoprotein on bovine neutrophil respiratory burst activity and IL-8 production.
During bacterial-mediated diseases, neutrophils (PMNs) play a critical role in defending the host against invading pathogens. PMN production of reactive oxygen species (ROS) contributes to the bactericidal capabilities of these cells. ROS are produced intracellularly and can be released extracellularly. The aberrant extracellular release of ROS, however, has been reported to induce injury to ho...
متن کاملHuman alpha1-acid glycoprotein binds to CCR5 expressed on the plasma membrane of human primary macrophages.
We have reported previously that human alpha(1)-acid glycoprotein (AGP) inhibits the infection of human monocyte-derived macrophages (MDM) by R5 HIV-1, and that a disulphide-bridged peptide mimicking the clade B HIV-1 gp120 consensus V3 domain (V3Cs) binds specifically to CCR5 (the major co-receptor of R5 HIV strains) on these cells [Seddiki, Rabehi, Benjouad, Saffar, Ferriere, Gluckman and Gat...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1990
ISSN: 0014-5793
DOI: 10.1016/0014-5793(90)80737-4